concept

INSULIN SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

754Connections

0Hypotheses

0Analyses

49Outgoing

14Incoming

Summary

INSULIN SIGNALING is a concept in neurodegeneration research. Key relationships include: transports, co discussed, causes. Associated with NEURODEGENERATION. Connected to 14 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	INSULIN SIGNALING
Key Genes/Proteins	TNF, APP, GLUT4, MAPT, APC
Related Diseases	ALZHEIMER'S DISEASE, INSULIN RESISTANCE, NEURODEGENERATION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INSULIN_SIGNALING["INSULIN SIGNALING"]
    INSULIN_SIGNALING -->|"interacts"| Cholesterol["Cholesterol"]
    INSULIN_SIGNALING -->|"interacts"| Glycolysis["Glycolysis"]
    INSULIN_SIGNALING -->|"interacts"| Mtor["Mtor"]
    INSULIN_SIGNALING -->|"interacts"| Synaptic_Plasticity["Synaptic Plasticity"]
    INSULIN_SIGNALING -->|"interacts"| Nf__b["Nf-Kappab"]
    IRS1["IRS1"] -->|"regulates"| INSULIN_SIGNALING
    PI3K_Akt_mTOR["PI3K-Akt-mTOR"] -->|"interacts"| INSULIN_SIGNALING
    PI3K_Akt_mTOR_pathway["PI3K-Akt/mTOR pathway"] -->|"interacts"| INSULIN_SIGNALING
    IGF_1["IGF-1"] -->|"regulates"| INSULIN_SIGNALING
    JUN["JUN"] -->|"activates"| INSULIN_SIGNALING
    MTOR["MTOR"] -->|"activates"| INSULIN_SIGNALING
    AKT["AKT"] -->|"activates"| INSULIN_SIGNALING
    GENES["GENES"] -->|"activates"| INSULIN_SIGNALING
    Obesity["Obesity"] -->|"activates"| INSULIN_SIGNALING
    Diabetes["Diabetes"] -->|"activates"| INSULIN_SIGNALING

Outgoing (121)

Target	Relation	Type	Str
TNF	activates	gene	0.70
ALZHEIMER'S DISEASE	treats	disease	0.65
NEURONS	activates	cell_type	0.65
APP	regulates	gene	0.65
INSULIN RESISTANCE	treats	phenotype	0.65
MTOR	co_discussed	entity	0.50
APC	associated_with	gene	0.50
PROTEOSTASIS	associated_with	phenotype	0.50
SQSTM1	associated_with	gene	0.50
BECN1	associated_with	gene	0.50
ATG12	associated_with	gene	0.50
LAMP1	associated_with	gene	0.50
FOXO1	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
ATG5	associated_with	gene	0.50
ATG7	associated_with	gene	0.50
ULK1	associated_with	gene	0.50
GLUT4	associated_with	gene	0.50
EPILEPSY	associated_with	disease	0.50
AMYLOID	associated_with	protein	0.50
GLUT1	associated_with	gene	0.50
TNF	associated_with	gene	0.50
JNK	associated_with	gene	0.50
P-TAU	associated_with	protein	0.50
GSK3B	associated_with	gene	0.50
PODOCYTES	associated_with	cell_type	0.50
PHOSPHO-TAU	associated_with	protein	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
CORTEX	associated_with	brain_region	0.50
RAPAMYCIN	associated_with	drug	0.45
MTOR	associated_with	gene	0.45
AUTOPHAGY	associated_with	phenotype	0.45
TAU	associated_with	protein	0.45
AMPK	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
GLAUCOMA	associated_with	disease	0.45
DEPRESSION	associated_with	disease	0.45
TLR4	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
ASTROCYTES	associated_with	cell_type	0.45
METFORMIN	associated_with	drug	0.45
LIRAGLUTIDE	associated_with	drug	0.45
MAPT	associated_with	gene	0.45
RESVERATROL	associated_with	drug	0.45
APOE	associated_with	gene	0.45
CYTOKINES	associated_with	phenotype	0.45
CERAMIDE	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
PICALM	associated_with	gene	0.45

Incoming (633)

Source	Relation	Type	Str
GLUT4	regulates	gene	0.65
NEURODEGENERATION	regulates	disease	0.65
NEURONS	causes	cell_type	0.65
RESVERATROL	treats	drug	0.65
ALZHEIMER'S DISEASE	degrades	disease	0.65
MAPT	implicated_in	gene	0.55
INSULIN RESISTANCE	participates_in	phenotype	0.55
MAPT	participates_in	gene	0.55
AKT	co_discussed	entity	0.50
TAU PHOSPHORYLATION	associated_with	phenotype	0.50
SYNAPTIC PLASTICITY	associated_with	phenotype	0.50
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
ENDOSOMAL TRAFFICKING	associated_with	phenotype	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

INSULIN SIGNALING

Understanding Entity Pages

Summary

Wiki Pages (20)

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Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

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TREM2 Mechanism Hub

GSK-3β in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

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Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Tauopathies